The emergence of mobile media has brought new opportunities and severe tests to the ideological and political education in universities. In order to improve and implement the effectiveness of ideological and political education of university students, we must fully realize that mobile media has become a new domain of ideological and political education. Ideological and political workers should strengthen the ideological and political education of university students under the influence of mobile media. This article takes the mobile phone media as a clue, and leads to the reflection of university students’ mental health education. It aims to promote the benign development of mobile media, and calls on the community to pay more attention to the psychological health education of university students. The multiple linear regression model is applied to study the influence of mobile phone media application on mental health education of university students, the positive and negative influence of mobile phone media on university students’ psychological health education in university students’ cognitive ability, communicative ability, life and emotion regulation ability and other aspects are obtained, and the improvement strategies are proposed.