This study aims at developing information technology to support the synthesis of scenarios for vocational guidance and workers’ rehabilitation based on collective expert knowledge integration. Collective expert knowledge is formalized by the conceptual modeling method. The functionally targeted approach enables the integration of collective expert knowledge at the stage of creating a conceptual model. The authors’ technologies for the synthesis of control algorithms based on the conceptual model are applied to synthesize and select scenarios for vocational guidance and workers’ rehabilitation. The application of the functionally targeted approach at the synthesis stage ensures the adequacy of relevant synthesized scenarios. Tree structures used in the functionally targeted approach are convenient for experts and allow them to build a hierarchical description of the main objects, processes, and relationships of the studied system in terms of the subject domain. This approach allows for rationally justified synthesis, and choice of psycho-physiological rehabilitation scenarios from the perspective of vocational rehabilitation goals.