Student Information System is one of the key systems for facilitating the management and development of Higher Education Institutions. Its use for academic decision-making purposes as well as other academic tasks is crucial. Therefore, this paper aims to understand the impact of System Quality, Information Quality and Information Presentation on Student Information System satisfaction of academic and administrative staff. In this study, System satisfaction survey is carried out and factor analysis and regression tests are applied to interpret the collected data. The results show that only Information Quality has direct effect on satisfaction. Then the impact of decision-making as a mediator factor on system satisfaction is measured and the results reveal that System Quality and Information Quality has indirect significant effect whereas Information Presentation does not have direct nor indirect effect on system satisfaction.