Sleep is the basic physiological needs of human beings, while sleep disorder commonly occur in the public. Bad sleep quality would result in bad work efficiency and low quality of life. Insomnia problem is regarded as a disease seriously affecting quality of life in current industrial and commercial societies. Medical education allows students presenting further cognition of self-health concepts and people understanding that proper physical activity could enhance citizens’ physical fitness, reduce the occurrence of chronic diseases, and largely help the expenditure of social medical expenses. Apparently, medical education is primary for human health. With experimental design, total 200 students in four classes of the University in Shanghai, as the research object, are proceeded 16-week (3hrs per week for total 48 hours) experimental teaching. The research results reveal the significant correlation between 1.medical education and sleep quality, 2.sleep quality and quality of life, and 3.medical education and quality of life. According to the results and findings, practical suggestions are proposed in this study, expecting to reinforce relevant medical education and draft lifestyles to enhance the sleep quality and quality of life.