Genetics is one of the very quickly developing disciplines and it influences all living people. Attitudes and perception of this field of science can influence motivation to studying genetics and it can create current or future participation in this topic. The main aim was to find out what high school students perceptions were of genetics by the using of semantic differential. The sample size was created by 102 students. The research tool was semantic differential included 20 seven points’ pairs of adjectives. Data was analysed by the methods descriptive (mean score), inferential (analysis of variance) and also multidimensional statistics (factor analysis). The perception of genetics is slightly positive and in the conclusion are suggested the proposals of further research.