Entrepreneurship Education in Colleges and universities is a profound reform of China's higher education paradigm. Which is a necessary choice for Chinese universities to break through the traditional educational model. It is an important measure to cultivate college students' entrepreneurial consciousness, entrepreneurship and entrepreneurial ability. On the whole, entrepreneurship education in China is still in the stage of exploration and rapid development. It is great practical significance and theoretical value to clarify the relationship between the entrepreneurship education quality and entrepreneurial intention. Based on this, this paper takes the social sciences, engineering and science students as the research object, and empirically explores the relationship among the entrepreneurship education quality, entrepreneurial orientation, entrepreneurial self-efficacy and entrepreneurial intention. We find that: (1) the quality of entrepreneurship education will positively affect entrepreneurial intention, and entrepreneurial self-efficacy plays as an intermediary role; (2) the relationship between the quality of entrepreneurship education and entrepreneurial self-efficacy will be affected by the adjustment of entrepreneurial orientation, the stronger the level of entrepreneurial orientation, the stronger the positive relationship between the entrepreneurship education quality and entrepreneurial self-efficacy; (3) the stronger the level of entrepreneurial orientation, the stronger the mediating effect between entrepreneurial self-efficacy and entrepreneurial intenti.